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Many women in their late 30s and early 40s begin to have premenstrual symptoms due to the changes in hormones experienced at this time. Studies have shown that estrogen levels may rise and progesterone levels fall as women enter perimenopause, and this is more pronounced in the premenstrual time. Estrogen may increase fluid retention in the body, as well as having a stimulant effect on the brain causing irritability. Other symptoms of "estrogen excess" include breast tenderness, insomnia, anxiety, and changes in the frequency and amount of the menstrual period.
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